Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
| Autor: | Musbah O. M. Tanira, Mehmet Simsek, Khalid Al Balushi, Khulood Al Lawatia, Hameedah Al Barawani, Riad A. Bayoumi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Sultan Qaboos University Medical Journal, Vol 5, Iss 1, Pp 9-14 (2003) |
| Druh dokumentu: | article |
| ISSN: | 2075-051X 2075-0528 |
| Popis: | Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|