Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration

Autor: Liz E. Lescano, Mario O. Salazar, Ricardo L. E. Furlan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-024-00456-w
Popis: Abstract The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thiocyanate as a source of bioactive compounds is described. The impact of the reaction on the chemical composition of the mixtures was qualitatively demonstrated through GC–MS, utilizing univariate and multivariate analysis. The reaction transformed most of the components in the natural mixtures, thereby expanding the chemical diversity of the mixtures. Changes in inhibition properties between natural and CEEOs were demonstrated through acetylcholinesterase TLC autography, resulting in a threefold increase in the number of positive events due to the modification process. The chemically engineered Origanum vulgare L. essential oil was subjected to bioguided fractionation, leading to the discovery of four new active compounds with similar or higher potency than eserine against the enzyme. The results suggest that the directed chemical transformation of essential oils can be a valuable strategy for discovering new acetylcholinesterase (AChE) inhibitors. Graphical Abstract
Databáze: Directory of Open Access Journals
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