Utilizing the glucose challenge test during pregnancy as a predictor of future diabetes risk

Autor: Meir Frankel, Noa Tsur, Rena Pollack, Anat Tsur
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 1471-2393
DOI: 10.1186/s12884-024-06874-5
Popis: Abstract Background Gestational Diabetes Mellitus (GDM) presents a significant health concern during pregnancy, predisposing individuals to future diabetes. Despite established postpartum diabetes screening guidelines, adherence to follow-up remains inadequate. Aims This study aimed to assess the predictive value of the 50-gram glucose challenge test (GCT) for post-pregnancy diabetes development. Materials and methods A population-based retrospective cohort study was conducted on pregnant women aged 18–45 who underwent GCT screening between November 2007 and July 2017 in a large Israeli community medical organization. Baseline characteristics, GCT results, and diabetes development during follow-up were analyzed using univariate and multivariate Cox regression analyses. Results Among 8,675 women included, 2.4% developed diabetes over a median follow-up of 73.23 months. Elevated GCT results correlated with a higher risk of future diabetes, with a 4% rise in risk per 1 mg/dL increase in glucose above 140 mg/dL. Multivariate analysis revealed a 60-fold rise in the risk of future diabetes in women with GCT results ≥ 200 mg/dL compared to those with GCT
Databáze: Directory of Open Access Journals
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