Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease
| Autor: | Giorgia Borio, Chiara Terracciano, Federico Buttafava, Andrea Vercelli, Laura Pagani, Chiara Zanzani, Alessandra Manicardi, Andrea Magnacavallo, Erika Poggiali |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Journal of Case Reports in Internal Medicine (2021) |
| Druh dokumentu: | article |
| ISSN: | 2284-2594 31874886 |
| DOI: | 10.12890/2021_002860 |
| Popis: | We report the case of a 62-year-old male patient fully vaccinated for COVID-19, admitted to our emergency room for persistent fever associated with exertional dyspnoea, skin lesions, diffuse myalgias and arthralgias not responsive to broad-spectrum antibiotic and antiviral therapy, who developed a rapidly progressive refractory to treatment interstitial lung disease due to anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, that required mechanical ventilation and ECMO. Here, we highlight the importance of always considering alternative diagnoses, i.e. viral and autoimmune diseases, including anti-MDA5 antibody screening, when dealing with patients with a skin rash, seronegative polyarthralgias and interstitial pneumonia, or acute respiratory distress syndrome of unknown origin. |
| Databáze: | Directory of Open Access Journals |
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