| Autor: |
Michelle Z.L. Kee, Ai Ling Teh, Andrew Clappison, Irina Pokhvisneva, Julie L. MacIssac, David T.S. Lin, Katia E. Ramadori, Birit F.P. Broekman, Helen Chen, Mary Lourdes Daniel, Neerja Karnani, Michael S. Kobor, Peter D. Gluckman, Yap Seng Chong, Jonathan Y. Huang, Michael J. Meaney |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 25, Iss 9, Pp 104860- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2022.104860 |
| Popis: |
Summary: Prenatal maternal mental health is a global health challenge with poorly defined biological mechanisms. We used maternal blood samples collected during the second trimester from a Singaporean longitudinal birth cohort study to examine the association between inter-individual genome-wide DNA methylation and prenatal maternal depressive symptoms. We found that (1) the maternal methylome was significantly associated with prenatal maternal depressive symptoms only in mothers with a female fetus; and (2) this sex-dependent association was observed in a comparable, UK-based birth cohort study. Qualitative analyses showed fetal sex-specific differences in genomic features of depression-related CpGs and genes mapped from these CpGs in mothers with female fetuses implicated in a depression-associated WNT/β-catenin signaling pathway. These same genes also showed enriched expression in brain regions linked to major depressive disorder. We also found similar female-specific associations with fetal-facing placenta methylome. Our fetal sex-specific findings provide evidence for maternal-fetal interactions as a mechanism for intergenerational transmission. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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