Vitamin D diminishes the high platelet aggregation of type 2 diabetes mellitus patients

Autor: Maya Sultan, Orit Twito, Tali Tohami, Erez Ramati, Eran Neumark, Gloria Rashid
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Platelets, Vol 30, Iss 1, Pp 120-125 (2019)
Druh dokumentu: article
ISSN: 0953-7104
1369-1635
09537104
DOI: 10.1080/09537104.2017.1386298
Popis: Platelet activation is found in inflammatory conditions and implicated in the pathogenesis of chronic medical conditions, such as atherosclerosis, coronary vascular disease, cerebrovascular disease, and diabetes mellitus (DM). HbA1c is inversely related to vitamin D25 levels in individuals with and without DM. This study aimed to determine the relation between platelet aggregation, vitamin D and HbA1c among healthy individuals and those with Type 2 DM (T2DM). The direct effect of vitamin D1, 25 (calcitriol) on platelet aggregation was also investigated. The study included four groups: A. normoglycemic Control group: HbA1c6.4%(+)Asp.; and D. DM not on aspirin therapy: HbA1c > 6.4%(−)Asp. Platelet aggregation was tested with and without calcitriol or saline pre-treatment, using collagen or adenosine diphosphate (ADP) as agonists. Platelet aggregation was higher in DM(−)Asp group compared to normoglycemic and DM(+)Asp, and higher, but not significant compared to pre-DM. The entire study population exhibited negative correlation between HbA1c and serum concentration of vitamin D25. Excluding DM(+)Asp, aggregation induced by collagen was significantly higher in patients with insufficient (
Databáze: Directory of Open Access Journals
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