Reduction of the occurrence of occult HBV infection in infants by increasing the dose of hepatitis B vaccine: a large prospective cohort study

Autor:	Yi Li, Zhixiu Liu, Yarong Song, Yiwei Xiao, Jing Jiang, Lili Li, Xiangjun Zhai, Jianxun Liu, Zhongping Duan, Feng Ding, Jia Liu, Hui Zhuang, Liguo Zhu, Jie Jiang, Huaibin Zou, Jie Wang, Jie Li
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Hepatitis B virus hepatitis B vaccine mother-to-child transmission occult hepatitis B virus infection post-vaccination serologic testing Infectious and parasitic diseases RC109-216 Microbiology QR1-502
Zdroj:	Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1881-1891 (2020)
Druh dokumentu:	article
ISSN:	22221751 2222-1751
DOI:	10.1080/22221751.2020.1808533
Popis:	ABSTRACTOccult hepatitis B virus (HBV) infection (OBI) has been observed among infants born to hepatitis B surface antigen (HBsAg)-positive mothers despite successful immunoprophylaxis. This study enrolled 549 infants [349 infants received a 10μg/dose of hepatitis B vaccine (HepB), and 200 infants received 20μg/dose HepB] born to HBsAg-positive mothers with HBV DNA load >6log10IU/mL. The anti-HBs levels in the 10μg group were significantly lower than that in the 20μg group both at 7 [652.48 (564.05-754.82) vs. 1541.72 (1268.69-1873.51) mIU/mL, P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c1b20319b9064058a68939bf99ff70a0 Zobrazit plný text záznamu View record in DOAJ