| Autor: |
Yanwei Wang, Kehan Xu, Guojing Bai, Lei Huang, Qiuye Wu, Weihua Pan, Shichong Yu |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 19, Iss 8, Pp 11333-11340 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules190811333 |
| Popis: |
Design and synthesis of triazole library antifungal agents having piperazine side chains, analogues to fluconazole were documented. The synthesis highlighted utilization of the click chemistry on the basis of the active site of the cytochrome P450 14α-demethylase (CYP51). Their structures were characterized by 1H-NMR, 13C-NMR, MS and IR. The influences of piperazine moiety on in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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