Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature

Autor: Geoffrey Alan Watson, Lorraine O’Neill, Ruth Law, Geraldine McCarthy, Douglas Veale
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Case Reports in Oncological Medicine, Vol 2015 (2015)
Druh dokumentu: article
ISSN: 2090-6706
2090-6714
DOI: 10.1155/2015/934039
Popis: Malignant disease may be associated with a wide variety of musculoskeletal syndromes. Rarely the musculoskeletal system can be indirectly affected by paraneoplastic phenomena, such as carcinomatous polyarthritis (CP). The differential diagnosis for CP is broad and is often a diagnosis of exclusion. CP often presents similarly to other forms of inflammatory arthritis, and a detailed history and physical examination can often distinguish CP from other more common causes of polyarticular arthritis. However serological tests such as rheumatoid factor (RF) and anti-citrullinated peptide (anti-CCP) antibody positivity, while rare, can be misleading. Clinical awareness and suspicion are paramount in achieving an accurate diagnosis and early detection of an occult neoplasm is critical for prompt management and therapy. We report two cases presenting with this unique clinical phenotype associated with paraneoplastic polyarthropathy and review the literature.
Databáze: Directory of Open Access Journals
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