Timing of hormone therapy and its association with cardiovascular risk and metabolic parameters in 4-vinylcyclohexene diepoxide-induced primary ovarian insufficiency mouse model

Autor:	Hyun Joo Lee, Min Jung Park, Jeong-Doo Heo, Bo Sun Joo, Jong Kil Joo
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Hormone therapy timing hypothesis primary ovarian insufficiency metabolic syndrome cardiovascular disease 4-vinylcyclohexene diepoxide Gynecology and obstetrics RG1-991 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Gynecological Endocrinology, Vol 39, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	09513590 1473-0766 0951-3590
DOI:	10.1080/09513590.2023.2247094
Popis:	Objective To evaluate the effects of various initiation time points and durations of hormone therapy (HT) on cardiovascular and metabolic parameters of premenarche, primary ovarian insufficiency (POI) mouse model, induced by 4-vinylcyclohexene diepoxide.Methods A total of 50 mice at 4 weeks of age were developed into POI mouse model, further randomly categorized into 5 groups: control group without any intervention; no HT group with only high-fat diet (NT); group 1 with delayed estradiol treatment (T1); group 2 with on-time, continuous estradiol treatment (T2); and group 3 with on-time estradiol treatment but early stop (T3). Cardiovascular risk and metabolic parameters were measured.Results Presenting with similar body weights, blood glucose levels of T1, T2, and T3 were all significantly lower than NT (p
Databáze:	Directory of Open Access Journals
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