| Autor: |
Jordan Houri, Roshan Karunamuni, Michael Connor, Niclas Pettersson, Carrie McDonald, Nikdokht Farid, Nathan White, Anders Dale, Jona A. Hattangadi-Gluth, Vitali Moiseenko |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Physics and Imaging in Radiation Oncology, Vol 6, Iss , Pp 39-46 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2405-6316 |
| DOI: |
10.1016/j.phro.2018.04.003 |
| Popis: |
Background and purpose: Brain radiotherapy (RT) can cause white matter damage and downstream neurocognitive decline. We developed a computational neuroimaging tool to regionally partition individual white matter tracts, then analyze regional changes in diffusion metrics of white matter damage following brain RT. Materials and methods: RT dose, diffusion metrics and white matter tract structures were extracted and mapped to a reference brain for 49 patients who received brain RT, and underwent diffusion tensor imaging pre- and 9–12 months post-RT. Based on their elongation, 23 of 48 white matter tracts were selected. The Tract-Crawler software was developed in MATLAB to create cross-sectional slice planes normal to a tract’s computed medial axis. We then performed slice- and voxel-wise analysis of radiosensitivity, defined as percent change in mean diffusivity (MD) and fractional anisotropy (FA) as a function of dose relative to baseline. Results: Distinct patterns of FA/MD radiosensitivity were seen for specific tracts, including the corticospinal tract, medial lemniscus, and inferior cerebellar peduncle, in particular at terminal ends. These patterns persisted for corresponding tracts in left and right hemispheres. Local sensitivities were as high as 40%/Gy (e.g., voxel-wise: −39 ± 31%/Gy in right corticospinal tract FA, −45 ± 25%/Gy in right inferior cerebellar peduncle FA), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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