| Autor: |
Juan José Martínez-García, Helios Martínez-Banaclocha, Diego Angosto-Bazarra, Carlos de Torre-Minguela, Alberto Baroja-Mazo, Cristina Alarcón-Vila, Laura Martínez-Alarcón, Joaquín Amores-Iniesta, Fátima Martín-Sánchez, Giovanni A. Ercole, Carlos M. Martínez, Ada González-Lisorge, José Fernández-Pacheco, Piedad Martínez-Gil, Sahil Adriouch, Friedrich Koch-Nolte, Juan Luján, Francisco Acosta-Villegas, Pascual Parrilla, Carlos García-Palenciano, Pablo Pelegrin |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-10626-x |
| Popis: |
Systemic sepsis is a potentially life-threatening illness and immunocompromised individuals are especially vulnerable. Here, using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome in establishing a host response, and NLRP3 dysfunction is a common feature of sepsis mortality. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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