Frailty Changes After Liver Transplantation. Results From a Spanish Multicenter Prospective Cohort Study
| Autor: | Lorena Puchades, MD, Julia Herreras, MD, Maria Àngels Cebrià i Iranzo, MD, PhD, Érick Reyes, MD, Gonzalo Crespo, MD, PhD, Manuel Rodríguez-Perálvarez, MD, PhD, Luis Cortés, MD, Trinidad Serrano, MD, PhD, Ainhoa Fernández-Yunquera, MD, Eva Montalvá, MD, PhD, Marina Berenguer, MD, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Transplantation Direct, Vol 10, Iss 4, p e1599 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2373-8731 00000000 68425074 |
| DOI: | 10.1097/TXD.0000000000001599 |
| Popis: | Introduction. Until now, there has been limited evidence, primarily from US cohorts, focusing on frailty as a patient-oriented outcome after liver transplantation (LT). Our study aimed to explore the relationship between pre- and post-LT frailty in a multicenter European cohort of outpatients with cirrhosis undergoing LT. Methods. We conducted a prospective analysis of data from 180 LT recipients recruited between 2018 and 2020 from 5 Spanish centers. Participants underwent objective and subjective frailty assessments using the Liver Frailty Index (LFI) and the Subjective Clinician Assessment (SCA) pretransplant and at 3- and/or 6-mo posttransplant. Results. The median pretransplant LFI was 3.9, showing minimal change at 3 mo (3.8; P = 0.331) and improvement at 6-mo post-LT (3.6; P = 0.001). Conversely, the SCA significantly improved early post-LT: at 3 mo, poor SCA decreased from 11% to 1%, and good SCA increased from 54% to 89% (P |
| Databáze: | Directory of Open Access Journals |
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