Combined Analytical Approaches to Standardize and Characterize Biomaterials Formulations: Application to Chitosan-Gelatin Cross-Linked Hydrogels

Autor:	Sofia Magli, Lorenzo Rossi, Cesare Consentino, Sabrina Bertini, Francesco Nicotra, Laura Russo
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	hybrid biomaterials gelatin chitosan Diels Alder hydrogels extracellular matrix Microbiology QR1-502
Zdroj:	Biomolecules, Vol 11, Iss 5, p 683 (2021)
Druh dokumentu:	article
ISSN:	11050683 2218-273X
DOI:	10.3390/biom11050683
Popis:	A protocol based on the combination of different analytical methodologies is proposed to standardize the experimental conditions for reproducible formulations of hybrid hydrogels. The final hybrid material, based on the combination of gelatin and chitosan functionalized with methylfuran and cross-linked with 4-arm-PEG-maleimide, is able to mimic role, dynamism, and structural complexity of the extracellular matrix. Physical–chemical properties of starting polymers and finals constructs were characterized exploiting the combination of HP-SEC-TDA, UV, FT-IR, NMR, and TGA.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1ab801c0a21f47a5a7ade174bae8094f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF