Asymmetric cross-aldol reaction of isatin and ketones catalyzed by crude earthworm extract as efficient biocatalyst
| Autor: | Fatemeh Shams, Javad Mokhtari Aliabad, Morteza Rouhani |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Green Chemistry Letters and Reviews, Vol 13, Iss 3, Pp 258-264 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1751-8253 1751-7192 17518253 |
| DOI: | 10.1080/17518253.2020.1808084 |
| Popis: | The asymmetric cross-aldol reaction of simple ketones (acetone, cyclohexanone) with isatin derivatives in the presence of crude extract from earthworms as green and effective biocatalyst proceeds easily in MeCN/H2O (1:1) as solvent to afford 3-hydroxy-2-oxindoles derivatives. Ten compounds were synthesized in high yields (62–88%) and moderate ee (29–42%). Structure of the synthesized compounds has been characterized on the basis of NMR spectra and CHN analysis. The ee of the obtained compounds was determined by chiral phase HPLC analysis. |
| Databáze: | Directory of Open Access Journals |
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