Patient Preferences for Nonvitamin K Antagonist Oral Anticoagulants in Stroke Prevention: A Multicountry Discrete Choice Experiment

Autor: Thomas Wilke, Anna-Katharina Meinecke, Bernhard Schaefer, Sandra Buchwald, Daniel Eriksson, Sabrina Müller
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Cardiology Research and Practice, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2090-8016
2090-0597
DOI: 10.1155/2019/5719624
Popis: Purpose. The patient’s perspective is becoming increasingly important in clinical and policy decisions. This study examined atrial fibrillation (AF) patient preferences for different characteristics of nonvitamin K antagonist oral anticoagulants (NOACs). Methods. A discrete choice experiment (DCE) addressing AF patients treated with NOACs in France, Germany, and the United Kingdom was conducted. The DCE included the following attributes: frequency of administration (once/twice daily), size of tablet/capsule (6–9 mm/20 mm), meal-related intake (intake with food required/independent), and distance to treating physician (1 km/10 km). Preferences were analyzed based on a conditional logit regression model. Results. In total, 758 patients (males: 57.3%; mean age: 71.4 years) with an average disease duration of 5.5 years were included (apixaban/dabigatran/edoxaban/rivaroxaban: 34.0%/14.5%/6.6%/44.9%, respectively). Patients preferred NOAC treatment options characterized by once-daily dosing regimens (42.8%; p
Databáze: Directory of Open Access Journals
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