| Autor: |
Fatemeh karami, Razieh Nazari, Hasan Adeli |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Kerman University of Medical Sciences, Vol 28, Iss 6, Pp 559-567 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2008-2843 |
| DOI: |
10.22062/jkmu.2021.91827 |
| Popis: |
Background: Drug resistant Acinetobacter baumannii have emerged as a major problem in many hospitals and intensive care units. The aim of this study was to determine the antibiotic resistance pattern and the prevalence of metallo-beta-lactamase genes among nosocomial A. baumannii isolates from Qom/ Iran.Methods: For this study, a total of 108 A. baumannii isolates were collected from hospitalized patients in four teaching hospitals of Qom/ Iran. Antibiotic susceptibility profile of isolates was tested by Kirby-Bauer disc diffusion method and distribution of MBL genes among carbapenem-resistant isolates was determined by polymerase chain reaction (PCR) method.Results: According to the results, 97 (89.81%) isolates of 108 A. baumannii isolates were resistant to carbapenem. All isolates carried bla oxa-51like gene. Among carbapenem resistant isolates, 79.38% carried bla VIM and 1.03% had bla IMP genes. Among the MBL- producing isolates, 7 isolates were MDR, 73 ones were XDR and 5 isolates were PDR.Conclusion: This study also revealed that suceptibility to carbapenems in the population of A. baumannii isolates reduced and the bla VIM gene was the most prevalent metallo-beta-lactamase genotype among carbapenem resistant A. baumannii isolates in this area. MBL-producing A. baumannii in recent years has become a serious concern. Rapid identification and good infection control are requiered to reduce their impact. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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