Prospects for the Search for New Antidiabetic Agents Among Vanadium-containing Complex Compounds (Review)
| Autor: | A. I. Krasnova, N. A. Pulina, T. A. Yushkova |
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| Jazyk: | ruština |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Разработка и регистрация лекарственных средств, Vol 12, Iss 4, Pp 19-27 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2305-2066 2658-5049 |
| DOI: | 10.33380/2305-2066-2023-12-4(1)-1603 |
| Popis: | Introduction. The epidemic increase in the incidence of diabetes mellitus (DM) makes it urgent to search for new antidiabetic agents. In clinical practice, there is an urgent question about improving and/or replacing insulin therapy for the disease. Vanadium compounds are of particular interest in connection with the identification of their multifactorial effects on the body, including insulin-like and hypoglycemic properties, which opens up prospects for the creation of a new generation of therapeutic agents for the treatment of types 1 and 2 diabetes. The focus of this review is on the structure and antidiabetic properties of vanadium complexes.Text. This review is devoted to the analysis of scientific literature on studies of vanadium-containing compounds as potential antidiabetic agents. The mechanisms of antidiabetic activity of vanadium-containing complex compounds are discussed. The prospects for searching for oxovanadium(IV) complexes with O4-coordination have been assessed.Conclusion. As a result of the analysis of the literature data, it was found that vanadium-containing complex compounds have a significant potential for use as antidiabetic agents. The relevance of the search for highly effective oxo-vanadium metal complexes based on ligands close to endogenous substrates, for example, based on derivatives of aroylpyruvic acid, is shown. |
| Databáze: | Directory of Open Access Journals |
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