Lipoprotein-associated phospholipase A2 and its possible association with COPD development: a case-control study

Autor: He Yu, Ying Yang, Jie Zhou, Mingxia Wu, Zongtao Chen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-7 (2024)
Druh dokumentu: article
ISSN: 1471-2466
DOI: 10.1186/s12890-024-03335-9
Popis: Abstract Background The association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with various cardiovascular events has been well-established. However, the exploration of its potential involvement in Chronic obstructive pulmonary disease (COPD) is currently limited. Therefore, our study aims to examine the relationship between Lp-PLA2 and pulmonary conditions, including emphysema, obstructive ventilatory dysfunction as well as small airway dysfunction, to provide further evidence of a possible association with COPD development. Methods Using data from the Southwest Hospital Health Management Center, spanning January 2013 to July 2024, we analyze relationship of serum Lp-PLA2 levels with diffuse pulmonary emphysema and pulmonary functions. In univariate analysis, group differences were assessed with t-tests for numerical variables and Chi-square tests for categorical data. Variables found to be statistically significant (two-sided P
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