| Autor: |
Hsin-Chung Lin, Chi-Hsiang Chung, Lih-Chyang Chen, Jui-Yang Wang, Chien-Chou Chen, Kuo-Yang Huang, Ming-Hang Tsai, Wu-Chien Chien, Hsin-An Lin |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-33674-2 |
| Popis: |
Abstract Pioglitazone is an insulin resistance inhibitor widely used as monotherapy or combined with metformin or insulin in treating type 2 diabetes mellitus (T2DM). This study further investigated the relationship between pioglitazone use and the risk of developing Alzheimer's disease (AD) in patients newly diagnosed with T2DM, and examined the potential impact of insulin use on this association. Data were extracted from the National Health Insurance Research Database (NHIRD) of Taiwan. Our data exhibited that the risk of developing AD in the pioglitazone group was 1.584-fold (aHR = 1.584, 95% CI 1.203–1.967, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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