| Autor: |
Kosuke Saito, Rika Ishikawa, Isao Kitamura, Kumiko Ogawa, Noriaki Arakawa, Yuchen Sun, Kazuo Imai, Takuya Maeda, Yoshiro Saito, Chihiro Hasegawa |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Pharmacological Sciences, Vol 150, Iss 2, Pp 49-55 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1016/j.jphs.2022.06.005 |
| Popis: |
The coronavirus disease 2019 (COVID-19) pandemic has been associated with high mortality worldwide. Owing to its complicated pathophysiology, diagnostic and prognostic biomarkers for effective patient management remain scarce. We analyzed kynurenine, tryptophan, and serotonin levels in the serum of patients with COVID-19 via liquid chromatography/mass spectrometry analysis. Serum serotonin levels were decreased in patients with more severe COVID-19, along with increased kynurenine and decreased tryptophan concentrations. Patients with moderate disease who subsequently worsened showed significantly lower serotonin concentrations compared with those who did not experience severe disease. Serum serotonin levels may represent a valuable biomarker for COVID-19 severity and prognosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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