CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells

Autor: Jennifer Serwanga, Susan Mugaba, Auma Betty, Edward Pimego, Sarah Walker, Paula Munderi, Charles Gilks, Frances Gotch, Heiner Grosskurth, Pontiano Kaleebu
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: AIDS Research and Treatment, Vol 2011 (2011)
Druh dokumentu: article
ISSN: 2090-1240
2090-1259
DOI: 10.1155/2011/875028
Popis: Objective. To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8+ T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n=42) and continuous treatment (CT) (n=46) before and after a single STI cycle when the DART STI trial was stopped early due to inferior clinical outcome in STI participants. Results. STI and CT had comparable magnitudes and breadths of monofunctional CD8+IFNγ+ and CD8+Perforin+ responses. However, STI was associated with significant decline in breadth of bi-functional (CD8+IFNγ+Perforin+) responses; P=.02, Mann-Whitney test. Conclusions. STI in individuals initiated onto ART at
Databáze: Directory of Open Access Journals
Externí odkaz: