A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias

Autor: Sebald A. N. Verkuijl, Estela Gonzalez, Ming Li, Joshua X. D. Ang, Nikolay P. Kandul, Michelle A. E. Anderson, Omar S. Akbari, Michael B. Bonsall, Luke Alphey
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34739-y
Popis: CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Here the authors use gene linkage to show that in males inheritance bias of wGDe did not occur by homing, rather through increased propagation of the donor drive element.
Databáze: Directory of Open Access Journals