DPP‐4抑制剂对接受胰岛素治疗的2型糖尿病患者冠状动脉疾病进展的影响

Autor: Young Choi, Seung‐Hyun Ko, Kiyuk Chang, Ki Dong Yoo, Sang‐Hyun Ihm
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Diabetes, Vol 15, Iss 11, Pp 944-954 (2023)
Druh dokumentu: article
ISSN: 1753-0407
1753-0393
DOI: 10.1111/1753-0407.13449
Popis: Abstract Background We evaluated the effect of a dipeptidyl peptidase‐4 inhibitor (DPP‐4i) on the progression of obstructive coronary artery disease (OCAD) in patients with type 2 diabetes mellitus (T2DM) receiving insulin therapy. Methods Using a multicenter clinical data warehouse, we analyzed the patients receiving insulin therapy for T2DM who underwent coronary computed tomography angiography (CCTA) for ≥2 times. The patients were divided into two groups according to the presence of DPP‐4i prescription between the two CCTA examinations. The prevalence of OCAD (>50% stenosis on CCTA), new revascularization rates, and changes in the coronary calcium score (CCS) were analyzed. Results A total of 623 patients were included, and a DPP‐4i was prescribed to 380 (60.9%) patients. The median time difference between the two CCTAs was 39.0 (17.0–61.4) months. Newly developed OCAD at the follow‐up CCTA was detected in 62 (16.3%) patients in the DPP‐4i group and 76 (31.3%) patients in the no DPP‐4i group (p
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