Serotype-Specific Pneumococcal Status prior to PCV 13 Administration in Children and Adolescents with Inflammatory Bowel Disease
| Autor: | Aleksandra Banaszkiewicz, Brygida Targońska, Kinga Kowalska-Duplaga, Katarzyna Karolewska-Bochenek, Agnieszka Sieczkowska, Agnieszka Gawrońska, Urszula Grzybowska-Chlebowczyk, Elżbieta Krzesiek, Izabella Łazowska-Przeorek, Maria Kotowska, Edyta Sienkiewicz, Jarosław Walkowiak, Hanna Gregorek, Andrzej Radzikowski, Piotr Albrecht |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Polish Journal of Microbiology, Vol 65, Iss 1 (2016) |
| Druh dokumentu: | article |
| ISSN: | 17331331 1733-1331 2544-4646 |
| DOI: | 10.5604/17331331.1197279 |
| Popis: | The aim of this study was to evaluate the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease (IBD) who were naïve to pneumococcal vaccination before administering the 13-valent pneumococcal conjugate vaccine (PCV 13). This was an open, prospective study on children and adolescents aged 5–18 years who had IBD and were naïve to pneumococcal vaccination. A single dose of PCV 13 was administered to each patient. The geometric mean concentrations (GMCs) were measured for all 13 serotypes. A total of 122 subjects completed the study. Prevaccination GMCs ranged from 0.55 μg/ml (serotype 4) to 4.26 μg/ml (serotype 19A). Prior to the administration of PCV 13, high GMCs were detected in older children and adolescents who had IBD and were naïve to pneumococcal vaccination. |
| Databáze: | Directory of Open Access Journals |
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