Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor
| Autor: | Maurizio Alletto, Antonio Burgio, Giovanni Fulco, Giulio Geraci, Concetta Groppuso, Gianfranco Gruttadauria, Elvio Manfrè, Gianluca Mastrosimone, Susanna Salvaggio, Giovanni Urrico, Federico Vancheri |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Italian Journal of Medicine (2020) |
| Druh dokumentu: | article |
| ISSN: | 1877-9344 1877-9352 |
| Popis: | Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GIST derive from mutations in tyrosine kinase receptors (KIT) or platelet-derived growth factor receptor-α (PDGFRA). GISTs are rarely associated with paraneoplastic hypoglycemia caused by non-β-cells tumor. This syndrome, defined non-islet cell tumor hypoglycemia (NICTH), arises from excess tumor production of insulin-like growth factor. We describe a 67-year-old female with severe NICTH secondary to an advanced and metastatic GIST. |
| Databáze: | Directory of Open Access Journals |
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