Safety and Effectiveness of Four-Factor Prothrombin Complex Concentrate in Special Populations with INR Below 2: A Post-Marketing Surveillance Study

Autor:	Masahiro Yasaka, Fumihiko Shimizu, Yuki Niwa, Ayako Kiyonaga, Naoki Terasaka
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Anticoagulants Bleeding International normalized ratio Intracranial hemorrhage Japan Prothrombin complex concentrate Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Cardiology and Therapy, Vol 13, Iss 3, Pp 603-614 (2024)
Druh dokumentu:	article
ISSN:	2193-8261 2193-6544
DOI:	10.1007/s40119-024-00380-7
Popis:	Abstract Introduction We previously conducted a prospective, observational post-marketing surveillance study to assess the safety and effectiveness of four-factor prothrombin complex concentrate (4F-PCC) for rapid vitamin K antagonist (VKA) reversal in Japanese patients. Methods This subgroup analysis compared the safety, especially thromboembolic events (TEEs), and effectiveness of 4F-PCC by stratifying patients into two subgroups according to baseline international normalized ratio (INR) levels with
Databáze:	Directory of Open Access Journals
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