Immunological and translational key challenges in systemic lupus erythematosus: A symposium update

Autor: Yves Renaudineau, Sylviane Muller, Christian M. Hedrich, Dominique Chauveau, Julie Bellière, Sébastien De Almeida, Jan Damoiseaux, Marc Scherlinger, Jean Charles Guery, Laurent Sailler, Chloé Bost
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Translational Autoimmunity, Vol 6, Iss , Pp 100199- (2023)
Druh dokumentu: article
ISSN: 2589-9090
DOI: 10.1016/j.jtauto.2023.100199
Popis: The first LBMR-Tim (Toulouse Referral Medical Laboratory of Immunology) symposium convened on December 16, 2022 in Toulouse, France to address challenging questions in systemic lupus erythematosus (SLE). Special focus was put on (i) the role played by genes, sex, TLR7, and platelets on SLE pathophysiology; (ii) autoantibodies, urinary proteins, and thrombocytopenia contribution at the time of diagnosis and during follow-up; (iii) neuropsychiatric involvement, vaccine response in the COVID-19 era, and lupus nephritis management at the clinical frontline; and (iv) therapeutic perspectives in patients with lupus nephritis and the unexpected adventure of the Lupuzor/P140 peptide. The multidisciplinary panel of experts further supports the concept that a global approach including basic sciences, translational research, clinical expertise, and therapeutic development have to be prioritized in order to better understand and then improve the management of this complex syndrome.
Databáze: Directory of Open Access Journals