Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors

Autor: Olívia Moreira Sampaio, Lucas Campos Curcino Vieira, Barbara Sayuri Bellete, Beatriz King-Diaz, Blas Lotina-Hennsen, Maria Fátima das Graças Fernandes da Silva, Thiago André Moura Veiga
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Molecules, Vol 23, Iss 10, p 2693 (2018)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules23102693
Popis: Eight alkaloids (1–8) were isolated from Ruta graveolens, and their herbicide activities were evaluated through in vitro, semivivo, and in vivo assays. The most relevant results were observed for Compounds 5 and 6–8 at 150 μM, which decreased dry biomass by 20% and 23%, respectively. These are significant results since they presented similar values with the positive control, commercial herbicide 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). Based on the performed assays, Compound 5 (graveoline) is classified as an electron-transport inhibitor during the light phase of photosynthesis, as well as a plant-growth regulator. On the other hand, Compounds 6–8 inhibited electron and energy transfers, and are also plant-growth inhibitors. These phytotoxic behaviors based on acridone and quinolone alkaloids may serve as a valuable tool in the further development of a new class of herbicides since natural products represent an interesting alternative to replace commercial herbicides, potentially due their low toxicity.
Databáze: Directory of Open Access Journals
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