Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers

Autor:	Renata Bordeira-Carriço, Joana Teixeira, Marta Duque, Mafalda Galhardo, Diogo Ribeiro, Rafael D. Acemel, Panos. N. Firbas, Juan J. Tena, Ana Eufrásio, Joana Marques, Fábio J. Ferreira, Telmo Freitas, Fátima Carneiro, José Luís Goméz-Skarmeta, José Bessa
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Science
Zdroj:	Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Druh dokumentu:	article
ISSN:	2041-1723
DOI:	10.1038/s41467-022-29551-7
Popis:	Alterations in cis-regulatory elements (CREs) can contribute to pancreatic diseases. Here the authors combine chromatin profiling and interaction points with in vivo reporter assays in zebrafish to uncover functionally equivalent human CREs, helping to predict disease-relevant enhancers.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1a526720f0e94a6eb3de65fc0179fea9 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ