Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats
| Autor: | Alireza Sarkaki, Maryam Rafieirad, Seyed Ebrahim Hossini, Yaghoub Farbood, Fereshteh Motamedi, Seyed Mohammad Taghi Mansouri, Bahareh Naghizadeh |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Iranian Journal of Basic Medical Sciences, Vol 16, Iss 9, Pp 1004-1010 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2008-3866 2008-3874 |
| Popis: | Objective(s): Cerebral hypoperfusion/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of grape seed extract (GSE) on passive avoidance memory and long-term potentiation (LTP) after permanent bilateral common carotid arteries occlusion (2CCAO) in male adult rats. Materials and Methods: Thirty-two adult male Wistar rats were randomly divided into: 1) Sham+Veh, 2) Isch+Veh, 3) Sham+GSE, 4) Isch+GSE. In order to make 2CCAO as an animal model of CHI, carotid arteries were ligatured and then cut bilaterally. To evaluation of passive avoidance memory, step-down latency (STL) was measured and LTP was recorded from hippocampal dentate gyrus (DG) after high frequency stimulation (HFS) in all rats. Results: We found that memory was significantly impaired in rats after CHI (P |
| Databáze: | Directory of Open Access Journals |
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