Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria

Autor:	Steve Biko Otieno, Alaa Altahan, Fnu Kaweeta, Saradasri Karri, Fnu Alnoor, Robert Johnson
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Case Reports in Hematology, Vol 2021 (2021)
Druh dokumentu:	article
ISSN:	2090-6560 2090-6579
DOI:	10.1155/2021/6619177
Popis:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.
Databáze:	Directory of Open Access Journals
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