Beneficial effects of riociguat on hemodynamic responses to exercise in CTEPH patients after balloon pulmonary angioplasty – A randomized controlled study

Autor: Tatsuo Aoki, Koichiro Sugimura, Yosuke Terui, Shunsuke Tatebe, Shigefumi Fukui, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Hideaki Suzuki, Haruka Sato, Katsuya Kozu, Ryo Konno, Satoshi Miyata, Kotaro Nochioka, Kimio Satoh, Hiroaki Shimokawa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Cardiology: Heart & Vasculature, Vol 29, Iss , Pp 100579- (2020)
Druh dokumentu: article
ISSN: 2352-9067
DOI: 10.1016/j.ijcha.2020.100579
Popis: Background: Although balloon pulmonary angioplasty (BPA) improves symptoms and pulmonary hemodynamics in patients with chronic thromboembolic pulmonary hypertension (CTEPH), the effects of riociguat on hemodynamics and exercise capacity in patients after BPA remain to be elucidated. Methods and Results: This study was a single-center, prospective, randomized, open-label trial. From November 2015 to November 2018, we prospectively examined 21 patients with CTEPH (65 ± 9 years old, M/F 2/19) who showed hemodynamic improvement with mean pulmonary arterial pressure (mPAP)
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