| Autor: |
Kukec Renata Rezonja, Grabnar Iztok, Vovk Tomaz, Mrhar Ales, Kovac Viljem, Cufer Tanja |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Radiology and Oncology, Vol 49, Iss 2, Pp 173-180 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1581-3207 |
| DOI: |
10.2478/raon-2014-0050 |
| Popis: |
Background. Chemotherapy with platinum agent and etoposide for small-cell lung cancer (SCLC) is supposed to be associated with intermediate risk (10-20%) of febrile neutropenia. Primary prophylaxis with granulocyte colonystimulating factors (G-CSFs) is not routinely recommended by the treatment guidelines. However, in clinical practice febrile neutropenia is often observed with standard etoposide/platinum regimen. The aim of this analysis was to evaluate the frequency of neutropenia and febrile neutropenia in advanced SCLC patients in the first cycle of standard chemotherapy. Furthermore, we explored the association between severe neutropenia and etoposide peak plasma levels in the same patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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