Vitamin D as a marker of cognitive decline in elderly Indian population
| Autor: | Tejal Kanhaiya Vedak, Vaishali Ganwir, Arun B Shah, Charles Pinto, Vikram R Lele, Alka Subramanyam, Hina Shah, Sudha Shrikant Deo |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Annals of Indian Academy of Neurology, Vol 18, Iss 3, Pp 314-319 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0972-2327 1998-3549 |
| DOI: | 10.4103/0972-2327.160052 |
| Popis: | Objectives: Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population. Materials and Methods: The study population consisted of patients with dementia (Group A, n = 32), mild cognitive impairment (MCI; Group B, n = 24), and elderly age-matched controls (Group C, n = 30). Measurement of serum levels of 25(OH)D and total homocysteine were done. Results: Significant decreased concentration of 25(OH)D and increased concentration of homocysteine was observed. Association of serum levels of vitamin D with markers of cognitive decline as well as serum homocysteine levels was observed in patients with dementia and MCI when compared to controls. Conclusion: Correlation of vitamin D with markers of cognitive decline and homocysteine opens a new door for early diagnosis of cognitive impairment. |
| Databáze: | Directory of Open Access Journals |
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