Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia

Autor: Gasic Vladimir, Zukic Branka, Stankovic Biljana, Janic Dragana, Dokmanovic Lidija, Lazic Jelena, Krstovski Nada, Dolzan Vita, Jazbec Janez, Pavlovic Sonja, Kotur Nikola
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Radiology and Oncology, Vol 52, Iss 3, Pp 296-306 (2018)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.2478/raon-2018-0034
Popis: Response to glucocorticoid (GC) monotherapy in the initial phase of remission induction treatment in childhood acute lymphoblastic leukemia (ALL) represents important biomarker of prognosis and outcome. We aimed to study variants in several pharmacogenes (NR3C1, GSTs and ABCB1) that could contribute to improvement of GC response through personalization of GC therapy.
Databáze: Directory of Open Access Journals