Diffusion Tensor Imaging Evaluation of Neural Network Development in Patients Undergoing Therapeutic Repetitive Transcranial Magnetic Stimulation following Stroke

Autor: Naoki Yamada, Ryo Ueda, Wataru Kakuda, Ryo Momosaki, Takahiro Kondo, Takuya Hada, Nobuyuki Sasaki, Takatoshi Hara, Atsushi Senoo, Masahiro Abo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Neural Plasticity, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2090-5904
1687-5443
DOI: 10.1155/2018/3901016
Popis: We aimed to investigate plastic changes in cerebral white matter structures using diffusion tensor imaging following a 15-day stroke rehabilitation program. We compared the detection of cerebral plasticity between generalized fractional anisotropy (GFA), a novel tool for investigating white matter structures, and fractional anisotropy (FA). Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) of 2400 pulses applied to the nonlesional hemisphere and 240 min intensive occupation therapy (OT) daily over 15 days. Motor function was evaluated using the Fugl-Meyer assessment (FMA) and Wolf Motor Function Test (WMFT). Patients underwent diffusion tensor magnetic resonance imaging (MRI) on admission and discharge, from which bilateral FA and GFA values in Brodmann area (BA) 4 and BA6 were calculated. Motor function improved following treatment (p
Databáze: Directory of Open Access Journals
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