Alkalinization Using Sodium Bicarbonate for COVID-19 Treatment: A Systematic Review and Meta-Analysis

Autor: Arman Shafiee MD, Kyana Jafarabady MD, Hassan Moltazemi MD, Mohammad Javad Amini MD, Mohammad Ali Rafiei MD, Amirhossein Akhondi MD, Sayed-Hamidreza Mozhgani PhD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Evidence-Based Integrative Medicine, Vol 29 (2024)
Druh dokumentu: article
ISSN: 2515-690X
2515690X
DOI: 10.1177/2515690X241258403
Popis: Background A systematic review and meta-analysis have been conducted to evaluate the efficacy of alkalinization for COVID-19 patients based on current evidence to determine the impact of alkalinization on COVID-19 outcomes. Methods We searched MEDLINE (Pubmed), Web of Science, Cochrane Library, and Clinicaltrials.gov for studies evaluating the efficacy of alkalinization up to 30 April 2023. Based on the PRISMA 2020 statement criteria a systematic review and meta-analysis of studies were performed. Results The results of our meta-analysis showed a significant reduction in mortality rate in the alkalinization group compared to controls (RR 0.73, 95% CI: 0.56-0.95; I2 = 0%). However, our subgroup analysis showed no significant improvement in RCT-only studies (RR 0.78, 95% CI: 0.59-1.05; I2 = 0%), the recovery rate was significantly higher in the alkalinization group (RR 2.13, 95% CI: 1.39-3.26; I2 = 0%), duration of recovery also has improved in alkalinization group (SMD 0.76, 95% CI: 0.33-1.18; I2 = 0%). The results of our meta-analysis showed a significant reduction in the duration of hospitalization in the alkalinization group compared to controls with very low certainty of evidence (SMD −0.66, 95% CI: −0.97 to −0.35; I2 = 36%). Conclusion With low certainty of evidence, alkalinization (by sodium bicarbonate) can be an efficient and safe adjuvant treatment for COVID-19 patients. Future randomized controlled trials are needed to strengthen the available evidence.
Databáze: Directory of Open Access Journals
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