Gastroenteropancreatic neuroendocrine tumours – an overview
| Autor: | Karol Maciejewski, Barbara Buchalska, Małgorzata Solnik, Marta Fudalej, Andrzej Deptała, Anna Badowska-Kozakiewicz |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Studia Medyczne, Vol 38, Iss 4, Pp 361-376 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1899-1874 2300-6722 |
| DOI: | 10.5114/ms.2022.122394 |
| Popis: | Neuroendocrine neoplasms (NENs) belong to a group of various tumours that can arise on many internal organs. Among NENs a large class of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) can be distinguished, which comprise neoplasms arising from the gastrointestinal tract and pancreas. Therefore, this review provides the current status of the World Health Organization classification of GEP-NETs as well as an overview of their clinical presentation, diagnosis, and treatment methods. GEP-NETs are generally divided into 5 groups: pancreatic NETs (PanNETs), gastric NETs (G-NETs), duodenal NETs (D-NETs), jejunoileal NETs (Je-Ile NETs), and neuroendocrine neoplasms of the large intestine. Moreover, in each group several subtypes have been introduced according to cell differentiation, mitotic rate, and Ki-67 index. Low- and intermediate-grade GEP-NETs are well differentiated, have a mitotic rate under 20, and a Ki-67 index under 20%. High-grade GEP-NETs, however, are characterized by poor differentiation, mitotic rate over 20, and Ki-67 index over 20%. |
| Databáze: | Directory of Open Access Journals |
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