| Autor: |
Steen Hylgaard Joergensen, Esben Soevsoe S. Hansen, Nikolaj Bøgh, Lotte Bonde Bertelsen, Rasmus Stilling Tougaard, Peter Bisgaard Staehr, Christoffer Laustsen, Henrik Wiggers |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss 2, Pp 101095- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1097-6647 |
| DOI: |
10.1016/j.jocmr.2024.101095 |
| Popis: |
ABSTRACT: Background: Hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging (HP [1-13C]pyruvate CMR) visualizes key steps in myocardial metabolism. The present study aimed to examine patients with heart failure (HF) using HP [1-13C]pyruvate CMR. Methods: A cross-sectional study of patients with HF and healthy controls using HP [1-13C]pyruvate CMR. Metabolic imaging was obtained using a cardiac-gated spectral-spatial excitation with spiral read-out acquisition. The metabolite signal was analyzed for lactate, bicarbonate, and the alanine signal. Metabolite signal was normalized to the total carbon signal (TC). At the 1-year follow-up, echocardiography was performed in all patients and HP [1-13C]pyruvate MRI in two patients. Results: We included six patients with ischemic heart disease (IHD), six with dilated cardiomyopathy, and six healthy controls. In patients, left ventricular ejection fraction (LVEF) correlated with lactate/bicarbonate (r = −0.6, p = 0.03) and lactate/TC (r = −0.7, p = 0.01). In patients with LVEF |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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