Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin
| Autor: | Е V Kobolev, V V Desyatsky, L S Godlevsky, V F Mustyatsu, G А Drozdova |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | RUDN Journal of Medicine, Vol 0, Iss 2, Pp 5-9 (2010) |
| Druh dokumentu: | article |
| ISSN: | 2313-0245 2313-0261 |
| Popis: | Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner. |
| Databáze: | Directory of Open Access Journals |
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