Reduced‐dose chemotherapy followed by blinatumomab in induction therapy for newly diagnosed B‐cell acute lymphoblastic leukemia

Autor:	Jing Lu, Huifen Zhou, Xin Zhou, Yonggong Yang, Laigen Tong, Miao Miao, Xiaofei Yang, Suning Chen
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	B‐cell acute lymphoblastic leukemia blinatumomab induction therapy reduced‐dose chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 13, Iss 5, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.7062
Popis:	Abstract Background Blinatumomab early‐line treatment in B‐cell precursor acute lymphoblastic leukemia (B‐ALL) might improve clinical outcomes. Methods We conducted a retrospective real‐world cohort analysis in 20 newly diagnosed B‐ALL patients who received reduced‐dose chemotherapy (idarubicin, vindesine, and dexamethasone) for 1–3 weeks, followed by blinatumomab for 1–4 weeks as an induction therapy. Results At the end of the induction therapy, a complete remission rate of 100% was achieved; 17 (85%) patients were minimal residual disease (MRD) negative (
Databáze:	Directory of Open Access Journals
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