| Autor: |
Giacomo Miserocchi, Massimo Bassi, Giovanni De Luca, Sebastiano Calpona, Francesco De Rosa, Alberto Bongiovanni, Elisabetta Parisi, Giandomenico Di Menna, Alessandro De Vita, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Silvia Vanni, Laura Capelli, Massimo Magnani, Giuseppe Meccariello, Claudio Vicini, Angelo Campobassi, Laura Mercatali, Toni Ibrahim |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 13 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2023.1245043 |
| Popis: |
BackgroundPolymorphous adenocarcinoma (PAC) represents the second most widespread neoplasm of the minor salivary glands. These tumors rarely develop a histological progression from low-grade to high-grade malignancy, named “high-grade transformation” (HGT). Only nine cases are described in literature.Case descriptionHere, we describe the case of a 76-year-old male patient with a PAC recurrence of the oral floor displaying HGT, and we explore the tumor cytomorphological features, genomic profiling, and the patient’s clinical management. The tumor mass was characterized by poorly atypical cellular elements with vesicular nuclei and comedonecrosis foci. The growth pattern was predominantly solid, tubular, and cribriform. The lesion did not show microsatellite instability or targeted molecular alterations. The case was successfully treated with radical surgery followed by radiotherapy.ConclusionWe report for the first time the recurrence of a PAC with HGT arising in the oral floor after 20 years from the primary lesion. These preliminary data and the literature analysis enhance the knowledge of this extremely rare disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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