Effects of huoxin formula on the arterial functions of patients with coronary heart disease

Autor: Yan Xu, Hongyi Hu, Yi Li, Rong Cen, Chengzeng Yao, Wenhuan Ma, Minhua Huang, Yahui Yin, Hongzhi Gao, Yongming Liu, Alexander Endler
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Pharmaceutical Biology, Vol 57, Iss 1, Pp 13-20 (2019)
Druh dokumentu: article
ISSN: 1388-0209
1744-5116
13880209
DOI: 10.1080/13880209.2018.1561726
Popis: Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day (n = 30)] and control [only cardiovascular drugs (n = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments. Results: After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all p
Databáze: Directory of Open Access Journals
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