Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis

Autor: Velia Cassano, Giuseppe Armentaro, Domenico Iembo, Sofia Miceli, Teresa V. Fiorentino, Elena Succurro, Maria Perticone, Franco Arturi, Marta L. Hribal, Tiziana Montalcini, Francesco Andreozzi, Giorgio Sesti, Arturo Pujia, Angela Sciacqua
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-10 (2024)
Druh dokumentu: article
ISSN: 1475-2840
DOI: 10.1186/s12933-024-02177-3
Popis: Abstract Background Platelets play an important role in the development of cardiovascular disease (CVD). Mean platelet volume (MPV) is considered as biological marker of platelets activity and function. The aim of the present study was to evaluate MPV values and its possible correlation with arterial stiffness and subclinical myocardial damage, in normal glucose tolerance patients (NGT), in newly diagnosed type 2 diabetic (T2DM) patients and in individuals with pre-diabetes. Methods We enrolled 400 newly diagnosed hypertensive patients. All patients underwent an Oral Glucose Tolerance test (OGTT). Arterial stiffness (AS) was evaluated with the measurement of carotid-femoral pulse wave velocity (PWV), augmentation pressure (AP) and augmentation index (AI). Echocardiographic recordings were performed using an E-95 Pro ultrasound system. Results Among groups there was an increase in fasting plasma glucose (FPG) (p
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