Changes of the glomerular size during the human fetal kidney development

Autor: Daković-Bjelaković Marija, Vlajković Slobodan, Čukuranović Rade, Antić Svetlana, Bjelaković Goran, Mitić Dejan
Jazyk: English<br />Serbian
Rok vydání: 2006
Předmět:
Zdroj: Srpski Arhiv za Celokupno Lekarstvo, Vol 134, Iss 1-2, Pp 33-39 (2006)
Druh dokumentu: article
ISSN: 0370-8179
DOI: 10.2298/SARH0602033D
Popis: Introduction. Newborns adaptation on postnatal conditions includes significant morphological and functional renal changes. Every kidney contains a constant number of nephrons, at the end of the nephrogenesis period, which extends from week 8 to 34 of gestation. Mature juxtamedullary nephrons possess higher filtration capacity than primitive superficial nephrons, which have insufficient vascularization. Objective. The objective of the study was to calculate an average glomerular diameter in cortical zones of the kidney during development, to define periods of their most intensive growth, and to record differences of glomerular size between different cortical zones. METHOD A total of 30 human fetal kidneys aged from IV to X lunar months were analyzed. Stereological methods were used for calculating the average glomerular diameter in superficial, intermediate and juxtamedullary zone of the kidney cortex. Results. Glomeruli in the superficial cortical zone had the lowest average diameter. The average glomerular diameter continually increased from IV lunar month (0.057±0.004 mm) to X lunar month (0.082±0.004 mm), with highly significant correlation with gestational age (r=0.755; p
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