Jail Fever (Epidemic Typhus) Outbreak in Burundi

Autor: D. Raoult, V. Roux, J.B. Ndihokubwayo, G. Bise, D. Baudon, G. Martet, R. Birtles
Jazyk: angličtina
Rok vydání: 1997
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 3, Iss 3, Pp 357-360 (1997)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid0303.970313
Popis: We recently investigated a suspected outbreak of epidemic typhus in a jail in Burundi. We tested sera of nine patients by microimmunofluorescence for antibodies to Rickettsia prowazekii and Rickettsia typhi. We also amplified and sequenced from lice gene portions specific for two R. prowazekii proteins: the gene encoding for citrate synthase and the gene encoding for the rickettsial outer membrane protein. All patients exhibited antibodies specific for R. prowazekii. Specific gene sequences were amplified in two lice from one patient. The patients had typical clinical manifestations, and two died. Molecular techniques provided a convenient and reliable means of examining lice and confirming this outbreak. The jail-associated outbreak predates an extensive ongoing outbreak of louse-borne typhus in central eastern Africa after civil war and in refugee camps in Rwanda, Burundi (1), and Zaire.
Databáze: Directory of Open Access Journals
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