Case report of a patient with stage IV lung adenocarcinoma and uncommon/compound EGFR mutations who responded to afatinib

Autor:	Hisanori Hirokawa, Hirokuni Hirata, Hayase Azuma, Kei Sugitate, Sayo Soda, Jun Matsushima, Yasutsugu Fukushima
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Case report Lung adenocarcinoma E709G L861Q EGFR Uncommon/compound mutation Diseases of the respiratory system RC705-779
Zdroj:	Respiratory Medicine Case Reports, Vol 51, Iss , Pp 102094- (2024)
Druh dokumentu:	article
ISSN:	2213-0071 43068510
DOI:	10.1016/j.rmcr.2024.102094
Popis:	There is no established treatment for lung adenocarcinoma with uncommon/compound epidermal growth factor receptor (EGFR) mutations. We report a case of a 73-year-old man with stage IVB lung adenocarcinoma harboring E709G and L861Q EGFR mutations. After 2 months of afatinib treatment, significant tumor shrinkage was observed, and the patient's condition remained stable for 1 year. This case highlights the potential effectiveness of afatinib for treating rare stage IV lung adenocarcinoma with these specific EGFR mutations.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/19c2fec20eac4306851054f2104beb36 Zobrazit plný text záznamu View record in DOAJ