| Autor: |
Ruggero Vigliaturo, Maja Jamnik, Goran Dražić, Marjetka Podobnik, Magda Tušek Žnidarič, Giancarlo Della Ventura, Günther J. Redhammer, Nada Žnidaršič, Simon Caserman, Reto Gieré |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Minerals, Vol 14, Iss 1, p 101 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2075-163X |
| DOI: |
10.3390/min14010101 |
| Popis: |
Amphibole asbestos is related to multiple diseases, mainly those targeting the lungs. Asbestos-related malignancies can also be caused by non-regulated asbestiform minerals and some elongated mineral particles (EMPs). In particular, the role of nano- and micro-sized EMPs internalized by lung epithelial cells must be clarified. This is of major importance when considering that EMPs to which humans are exposed are likely a highly heterogeneous mix of different mineral types, shapes, and sizes. Here, we document that particles smaller than 4.54 µm in length and smaller than 0.89 µm in width (e.g., particles that do not fit the regulatory categories to be identified as asbestos) are easily internalized because of their specific dimensions, surface charge, and shape (mostly dictated by the aspect ratio L/w). Once internalized, these particles can be found in proximity to the cell nucleus, in vesicles, and in the cytoplasm. Examining the localization of particles in cells provides important information, which helps in determining the physicochemical environment found inside the biological compartment, thus allowing for a better comprehension of the mineralogical transformation that might happen after internalization by cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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