| Autor: |
Isabel D. Colón-Bernal, Le T. Duong, Brenda Pennypacker, James Henderson, Kenneth M. Kozloff, Mark M. Banaszak Holl |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Bone Reports, Vol 9, Iss , Pp 159-164 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2352-1872 |
| DOI: |
10.1016/j.bonr.2018.10.001 |
| Popis: |
Anti-resorptive drugs treat bone loss by blocking osteoclast activity through a variety of mechanisms of action. Once significant bone loss has occurred, the ability to restore biomechanical function may differ based on the drug chosen. To assess this question, bisphosphonate (alendronate, ALN) and cathepsin K inhibitor (MK-0674, CatKi) were employed in treatment mode to compare the relative changes to cancellous bone microstructure and mechanical properties in ovariectomized (OVX) cynomolgus monkeys. Lumbar vertebrae (LV) bone mineral density (BMD) values taken two years post-surgery prior to drug treatment show a 10–15% decrease (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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